Journal of Foot and Ankle Surgery
Volume 42, Issue 1 , Pages 2-8 , January 2003

Rapid diagnosis of pedal osteomyelitis in diabetics with a technetium-99m-labeled monoclonal antigranulocyte antibody

References 

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  2. Thakur ML, Marcus CS, Henneman P, Butler J, Sinow R, Diggles L, et al. Imaging inflammatory diseases with neutrophil-specific technetium-99m-labeled monoclonal antibody anti-SSEA-1. J Nucl Med. 1996;37:1789–1795
  3. Mozley PD, Thakur ML, Alavi A, Smith T, Barraclough ED, Wilding P, et al. Effects of a 99mTc-labeled murine immunoglobulin M antibody to CD 15 antigens on human granulocyte membranes in healthy volunteers. J Nucl Med. 1999;40:2107–2114
  4. Gratz S, Behr T, Herrmann A, Dressing K, Tarditi L, Franchesini R, et al. Intraindividual comparison of 99mTc-labelled anti-SSEA-1 antigranulocyte antibody and 99mTc-HMPAO labelled white blood cells for the imaging of infection. Eur J Nucl Med. 1998;25:386–393
  5. Kipper SL, Rypins EB, Evans DG, Thakur ML, Smith TD, Rhodes B. Neutrophil-specific Tc-99m-labeled anti-CD 15 monoclonal antibody imaging for diagnosis of equivocal appendicitis: clinical evaluation of safety, efficacy and time performance characteristics. J Nucl Med. 2000;41:449–455
  6. Thakur ML, Lavender JP, Arnot RN, Silvester DJ, Segal AW. Indium-111-labeled autologous leukocytes in man. J Nucl Med. 1977;18:1014–1021
  7. Newman LG, Waller J, Palestro CJ, Schwartz M, Klein MJ, Hermann G, et al. Unsuspected osteomyelitis in diabetic foot ulcers: diagnosing and monitoring by leukocyte scanning with In-111 oxyquinoline. JAMA. 1991;266:1246–1251
  8. Larcos G, Brown ML, Sutton RT. Diagnosis of osteomyelitis of the foot in diabetic patients: value of 111In-leukocyte scintigraphy. AJR Am J Roentgenol. 1991;157:527–531
  9. Bamburger DM, Daus GP, Gerding DN. Osteomyelitis in the feet of diabetic patients. Long term results, prognostic factors, and the role of antimicrobial and surgical therapy. Am J Med. 1987;83:653–660
  10. Grayson ML, Gibbons GW, Baylogh K, Levin E, Karchmer AW. Probing to bone in infected pedal ulcers. A clinical sign of underlying osteomyelitis in diabetic patients. JAMA. 1995;273:721–723
  11. Palestro CJ, Tomas MB. Scintigraphic evaluation of the diabetic foot. In:  Freeman LM editors. Nuclear Medicine Annual. Philadelphia: Williams and Wilkins,; 2000;p. 143–172
  12. Devillers A, Moisan A, Hennion F, Garin E, Poirier JY, Bourget P. Contribution of technetium-99m hexamethylpropylene amine oxime labelled leucocyte scintigraphy to the diagnosis of diabetic foot infection. Eur J Nucl Med. 1998;25:132–138
  13. Blume PA, Dey HM, Daley LJ, Arrighi JA, Soufer R, Gorecki GA. Diagnosis of pedal osteomyelitis with Tc-99m HMPAO labeled leukocytes. J Foot Ankle Surg. 1997;36:120–126
  14. Palestro CJ, Mehta HH, Patel M, Freeman SJ, Harrington WN, Tomas MB, et al. Marrow versus infection in the Charcot joint: indium-111 leukocyte and technetium-99m sulfur colloid scintigraphy. J Nucl Med. 1998;39:346–350

☆ Address correspondence to: Christopher J. Palestro, MD, Division of Nuclear Medicine, Long Island Jewish Medical Center, 270-05 76th Ave, New Hyde Park, NY 11040. e-mail: palestro@lij.edu.

☆☆ Supported by a grant from Palatin Technologies, Inc., Princeton, NJ; research grants from Palatin Technologies (C.J.P., S.L.K., F.L.W.); honoraria from Palatin Technologies (C.J.P., S.L.K.). S.L.K. is a stockholder in Palatin Technologies.

PII: S1067-2516(03)70045-3

doi: 10.1053/jfas.2003.0420001

Journal of Foot and Ankle Surgery
Volume 42, Issue 1 , Pages 2-8 , January 2003

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