Journal of Foot and Ankle Surgery
Volume 49, Issue 1 , Pages 75-79, January 2010

Malignant Transformation of a Chronic Venous Stasis Ulcer to Basal Cell Carcinoma in a Diabetic Patient: Case Study and Review of the Pathophysiology

  • Molly Schnirring-Judge, DPM, FACFAS

      Affiliations

    • Faculty Graduate Medical Education, Mercy Hospital Health Systems, Toledo, OH; Director; Research and Publications, Kaiser Permanente, Cleveland, OH; Adjunct Clinical Faculty, Ohio University, Athens, OH
    • Corresponding Author InformationAddress correspondence to Molly S. Judge, DPM, FACFAS, 7581 Secor Road, Lambertville, Michigan 48144.
    • ,
  • Drew Belpedio, DPM

      Affiliations

    • PGY-III, St. Vincent Mercy Hospital, Mercy Hospital Health Systems, Toledo, OH

Abstract 

The degeneration of chronic wounds into basal cell carcinoma is rare. We present an atypical case of basal cell carcinoma diagnosed by soft tissue biopsy in a long-standing wound that had been treated for 3 years as a chronic venous stasis ulcer. In addition to the case report, we review the biomedical literature describing malignant transformation of long-standing wounds. Foot and ankle specialists should be on the lookout for changes that signal malignant transformation in long-standing ulcers.

Level of Clinical Evidence: 4

Keywords: cancer, neoplasm, squamous cell, wound, surgery

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 Financial Disclosure: None reported.

 Conflict of Interest: None reported.

PII: S1067-2516(09)00291-9

doi:10.1053/j.jfas.2009.07.015

Journal of Foot and Ankle Surgery
Volume 49, Issue 1 , Pages 75-79, January 2010

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