Journal of Foot and Ankle Surgery
Volume 49, Issue 5 , Pages 489.e5-489.e9 , September 2010

Disseminated Intravascular Coagulation, Meningococcal Infection, and Ischemic Changes Affecting the Lower Extremities: A Case Study

  • Jessica L. Herzog, DPM

      Affiliations

    • Submitted during 3rd year residency, Highlands Presbyterian/St. Luke’s Denver Podiatric Surgical Residency, Denver, CO
    • ,
  • Kenneth P. Morgan, DPM, FACFAS

      Affiliations

    • Attending physician, Highlands Presbyterian/St. Luke’s Denver Podiatric Surgical Residency, Denver, CO
    • ,
  • Matthew H. Paden, DPM, FACFAS

      Affiliations

    • Director of Residency Education, Highlands Presbyterian/St. Luke’s Denver Podiatric Surgical Residency, Denver, CO
    • ,
  • Paul A. Stone, DPM, FACFAS

      Affiliations

    • Director of Research, Highlands Presbyterian/St. Luke’s Denver Podiatric Surgical Residency, Denver, CO
    • Corresponding Author InformationAddress correspondence to: Paul. A. Stone, DPM, 5375 South Florence Ct, Greenwood Village, CO 80111.

References 

  1. Angyo IA, Okpeh ES. Changing patterns of antibiotic sensitivity and resistance during an outbreak of meningococcal infection in Jos, Nigeria. J Trop Pediatr. 1998;44:263–265
  2. Thompson MJ, Ninis N, Perera R, Mayon-White R, Phillips C, Bailey L, et al. Clinical recognition of meningococcal disease in children and adolescents. Lancet. 2006;367:397–403
  3. Anonymous. Control and prevention of serogroup C meningococcal disease: evaluation and management of suspected outbreaks. MMWR Mortal Wkl Rep. 1997;46:13–21
  4. Carpenter RR, Petersdorf RG. The clinical spectrum of bacterial meningitis. Am J Med. 1962;33:262–275
  5. Dellinger RP, Carlet JM, Masur H, Gerlach H, Calandra T, Cohen J, et al. Surviving Sepsis Campaign guidelines for management of severe sepsis and septic shock. Crit Care Med. 2004;32(3):858–873
  6. O'Neil KM. Complement deficiency. Clin Rev Allergy Immunol. 2000;19:83–108
  7. Wen L, Atkinson JP, Giclas PC. Clinical and laboratory evaluation of complement deficiency. J Allergy Clin Immunol. 2004;133:585–593
  8. Levi MJ, van der Poll T. New treatment strategies for disseminated intravascular coagulation based on current understanding of pathophysiology. Ann Med. 2004;41–49
  9. Alberio L, Lammle B, Esmon CT. Protein C replacement in severe meningococcemia: rational and clinical experience. Clin Infect Dis. 2001;32:1338–1346
  10. Faust SN, Levin M, Harrison OB, Goldin RD, Lockhart MS, Kondaveeti S, et al. Dysfunction of endothelial protein C activation in severe meningococcal sepsis. N Engl J Med. 2001;345:408–416
  11. Algren JT, Lal S, Cutliff SA, Richman BJ. Predictors of outcome in acute meningococcal infection in children. Crit Care Med. 1993;21:447–452
  12. Darmstadt GL. Acute infectious purpura fulminans: pathogenesis and medical management. Pediatr Dermatol. 1998;15:169–183
  13. Wilde JT, Roberts KM, Greaves M, Preston FE. Association between necropsy evidence of disseminated intravascular coagulation and coagulation variables before death in patients in intensive care units. J Clin Pathol. 1988;41:138–142

 Financial Disclosure: None reported.

 Conflict of Interest: None reported.

PII: S1067-2516(10)00128-6

doi: 10.1053/j.jfas.2010.04.005

Journal of Foot and Ankle Surgery
Volume 49, Issue 5 , Pages 489.e5-489.e9 , September 2010

Article Tools

* Image Usage & Resolution