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Tips, quips, and pearls| Volume 46, ISSUE 2, P139-142, March 2007

Technique of the Sural Nerve Biopsy

  • Author Footnotes
    1 Fellow, Center for Lower Extremity Ambulatory Research (CLEAR), Clinical Instructor; Department of Surgery, Dr. William M. Scholl College of Podiatric Medicine at Rosalind Franklin University of Medicine and Science, North Chicago, IL.
    Nicholas J. Bevilacqua
    Footnotes
    1 Fellow, Center for Lower Extremity Ambulatory Research (CLEAR), Clinical Instructor; Department of Surgery, Dr. William M. Scholl College of Podiatric Medicine at Rosalind Franklin University of Medicine and Science, North Chicago, IL.
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  • Author Footnotes
    2 Fellow, Center for Lower Extremity Ambulatory Research (CLEAR), Clinical Instructor; Department of Surgery, Dr. William M. Scholl College of Podiatric Medicine at Rosalind Franklin University of Medicine and Science, North Chicago, IL.
    Lee C. Rogers
    Footnotes
    2 Fellow, Center for Lower Extremity Ambulatory Research (CLEAR), Clinical Instructor; Department of Surgery, Dr. William M. Scholl College of Podiatric Medicine at Rosalind Franklin University of Medicine and Science, North Chicago, IL.
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  • Author Footnotes
    3 Senior Lecturer and Consultant Physician, Cardiovascular Research Group, Division of Cardiovascular and Endocrine Sciences, Manchester Royal Infirmary and University of Manchester, Manchester, United Kingdom.
    Rayaz A. Malik
    Footnotes
    3 Senior Lecturer and Consultant Physician, Cardiovascular Research Group, Division of Cardiovascular and Endocrine Sciences, Manchester Royal Infirmary and University of Manchester, Manchester, United Kingdom.
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  • Author Footnotes
    4 Director, Center for Lower Extremity Ambulatory Research (CLEAR), Professor of Surgery and Associate Dean, Dr. William M. Scholl College of Podiatric Medicine at Rosalind Franklin University of Medicine and Science, North Chicago, IL.
    David G. Armstrong
    Correspondence
    Address correspondence to: David G. Armstrong, DPM, PhD, Director, Center for Lower Extremity Ambulatory Research (CLEAR), Professor of Surgery and Associate Dean, Dr. William M. Scholl College of Podiatric Medicine, Rosalind Franklin University of Medicine and Science, 3333 Green Bay Rd, North Chicago, IL 60064.
    Footnotes
    4 Director, Center for Lower Extremity Ambulatory Research (CLEAR), Professor of Surgery and Associate Dean, Dr. William M. Scholl College of Podiatric Medicine at Rosalind Franklin University of Medicine and Science, North Chicago, IL.
    Search for articles by this author
  • Author Footnotes
    1 Fellow, Center for Lower Extremity Ambulatory Research (CLEAR), Clinical Instructor; Department of Surgery, Dr. William M. Scholl College of Podiatric Medicine at Rosalind Franklin University of Medicine and Science, North Chicago, IL.
    2 Fellow, Center for Lower Extremity Ambulatory Research (CLEAR), Clinical Instructor; Department of Surgery, Dr. William M. Scholl College of Podiatric Medicine at Rosalind Franklin University of Medicine and Science, North Chicago, IL.
    3 Senior Lecturer and Consultant Physician, Cardiovascular Research Group, Division of Cardiovascular and Endocrine Sciences, Manchester Royal Infirmary and University of Manchester, Manchester, United Kingdom.
    4 Director, Center for Lower Extremity Ambulatory Research (CLEAR), Professor of Surgery and Associate Dean, Dr. William M. Scholl College of Podiatric Medicine at Rosalind Franklin University of Medicine and Science, North Chicago, IL.
      A sural nerve biopsy may be useful to enable the clinician to diagnose the etiology and underlying pathology of patients presenting with symptoms of a peripheral neuropathy, when no clear underlying cause has been determined with conventional assessment such as electrophysiology or quantitative sensory testing. Given the prevalence of lower extremity neurological pathology, it is surprising that few descriptions in the peer-reviewed medical literature exist on the rationale and technique for biopsy of the sural nerve. We review the usefulness of this procedure, describe the technique, and discuss the potential complications.

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      References

        • Adler A.I.
        • Boyko E.J.
        • Ahroni J.H.
        • Stensel V.
        • Forsberg R.C.
        • Smith D.G.
        Risk factors for diabetic peripheral sensory neuropathy.
        Diabetes Care. 1997; 20: 1162-1167
        • de Neeling J.N.
        • Beks P.J.
        • Bertelsmann F.W.
        • Heine R.J.
        • Bouter L.M.
        Peripheral somatic nerve function in relation to glucose tolerance in an elderly Caucasian population: the Hoorn study.
        Diabet Med. 1996; 13: 960-966
        • Dyck P.J.
        • Kratz K.M.
        • Karnes J.L.
        • Litchy W.J.
        • Klein R.
        • Pach J.M.
        • Wilson D.M.
        • O’Brien P.C.
        • Melton 3rd, L.J.
        • Service F.J.
        The prevalence by staged severity of various types of diabetic neuropathy, retinopathy, and nephropathy in a population-based cohort: the Rochester Diabetic Neuropathy Study.
        Neurology. 1993; 43: 817-824
        • Boulton A.J.
        Chronic inflammatory demyelinating polyneuropathy and diabetes.
        Curr Diab Rep. 2003; 3: 437-438
        • McLeod J.G.
        Sural nerve biopsy.
        J Neurol Neurosurg Psychiatry. 2000; 69: 431
        • Grant I.A.
        Differential diagnosis of diabetic neuropathies.
        in: Dyck P.J. Thomas P.K. Diabetic Neuropathy. ed 2. Philadelphia, WB Saunders1999: 415-444
        • Dyck P.J.
        • Dyck P.J.B.
        • Englestad J.
        Pathologic alterations of nerves.
        in: Dyck P.J. Thomas P.K. Peripheral Neuropathy. ed 4. Philadelphia, Elsevier Saunders2005: 733-741
        • Ruth A.
        • Schulmeyer F.
        • Roesch M.
        • Woertgen C.
        • Brawanski A.
        Diagnostic and therapeutic value due to suspected diagnosis, long-term complications, and indication for sural nerve biopsy.
        Clin Neurol Neurosurg. 2004; : 214-217
        • Dyck P.J.
        • Dyck B.
        • Engelstad J.
        Pathologic Alterations of Nerves. ed 4. WB Saunders, Philadelphia2005
        • Kumar S.
        • Jacob S.
        Variability in the extent of sensory deficit after sural nerve biopsy.
        Neurology India. 2004; 52: 436-438
        • Theriault M.
        • Dort J.
        • Sutherland G.
        • Zochodne D.W.
        A prospective quantitative study of sensory deficits after whole sural nerve biopsies in diabetic and nondiabetic patients.
        Neurology. 1998; 50: 480-484
        • Solders G.
        Discomfort after fascicular sural nerve biopsy.
        Acta Neurol Scand. 1988; 77: 503-504
        • Dahlin L.B.
        • Eriksson K.F.
        • Sundkvist G.
        Persistent postoperative complaints after whole sural nerve biopsies in diabetic and non-diabetic subjects.
        Diabet Med. 1997; 14: 353-356
        • Gabriel C.
        • Howard R.
        • Kinsella N.
        • Lucas S.
        • McColl I.
        • Saldanha G.
        • Hall S.M.
        • Hughes R.A.
        Prospective study of the usefulness of sural nerve biopsy.
        J Neurol Neurosurg Psychiatry. 2000; 69: 442-444
        • Pollock M.
        • Nukada H.
        • Taylor P.
        • Donaldson I.
        • Carroll G.
        Comparison between fascicular and whole sural nerve biopsy.
        Ann Neurol. 1983; 13: 65-68