Abstract
Low-grade fibromyxoid sarcoma is a rare tumor, which most commonly arises from the
deep soft tissues of the lower extremities in young men. Diagnosis of this tumor can
be difficult because of its deceptively benign histopathologic appearance. Specifically,
the lesion is characterized by alternating fibrous and myxoid areas with variable
cellularity and a whorled growth pattern. Like many soft tissue tumors, low-grade
fibromyxoid sarcoma is also characterized by strong immunoreactivity to the human
proto-oncogene BCL-2. Cytogenetically, the lesion has also been associated with the
t (7,16) (q33;p11) translocation, with the characteristic resultant FUS and CREB3L2
fusion gene. In this report, we describe the rare case of a low-grade fibromyxoid
sarcoma that appeared to develop as a primary malignancy in the neck of the talus
of a young man who presented with recurrent ankle pain after a previous surgery for
a cystic lesion at the same site.
Level of Clinical Evidence
Keywords
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References
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Article info
Publication history
Published online: May 31, 2010
Footnotes
Financial Disclosure: None reported.
Conflict of Interest: None reported.
Identification
Copyright
© 2010 American College of Foot and Ankle Surgeons. Published by Elsevier Inc. All rights reserved.
