Abstract
Ewing's Sarcoma family of tumors are rare, malignant round cell tumors arising from
undifferentiated mesenchymal cells. This aggressive neoplastic disease has a quick
metastatic onset often resulting in a poor prognosis. In this case study we present
a 21-year-old female diagnosed with Ewing's sarcoma of the third metatarsal bone.
She initially presented in the emergency room with a 2-day onset of right foot pain
following a minor injury. Radiographs taken in the emergency room revealed a cystic
lesion in the third metatarsal. The patient presented to the author's clinic and following
evaluation, surgical excision and curettage of the bone cyst was performed supplemented
with allogenic bone graft. Due to a high clinical suspicion of malignancy, intraoperative
culture and biopsy of the third metatarsal were sent to pathology and microbiology.
Following evaluation of the bone biopsy with immunohistochemical staining as well
as fluorescent in-situ hybridization studies, a diagnosis was made for Ewing's Sarcoma.
This case report serves to display the significance of a timely workup as well as
the importance of multiple pathology assessments to obtain a definitive pathologic
diagnosis when clinical suspicion of malignancy is high.
Level of Clinical Evidence
Keywords
To read this article in full you will need to make a payment
Purchase one-time access:
Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online accessOne-time access price info
- For academic or personal research use, select 'Academic and Personal'
- For corporate R&D use, select 'Corporate R&D Professionals'
Subscribe:
Subscribe to The Journal of Foot and Ankle SurgeryAlready a print subscriber? Claim online access
Already an online subscriber? Sign in
Register: Create an account
Institutional Access: Sign in to ScienceDirect
References
- Ewing's sarcoma.Lancet Oncol. 2010; 11: 184-192
- Ewing's sarcoma with distant metastasis: a brief note on management and emerging therapies.Clin Pract. 2019; 9: 1111
DeLaney TF, Hornicek FJ. Clinical presentation, staging, and prognostic factors of the Ewing sarcoma family of tumors. Available at: https://www.uptodate.com/contents/clinical-presentation-staging-and-prognostic-factors-of-the-Ewing-sarcoma-family-of-tumors. Accessed August 27, 2020.
- Risk of recurrence and survival after relapse in patients with Ewing sarcoma.Pediatr Blood Cancer. 2011; 57: 549-553
- Ewing's sarcoma family of tumors: current management.Oncologist. 2006; 11: 503-519
- Role of radiation therapy in adult extraskeletal Ewing's sarcoma patients treated with chemotherapy and surgery.Sarcoma. 2019; 2019: 1-6
- Phenolization, and cementation in paediatric Ewing's sarcoma with a complete radiological response to neoadjuvant chemotherapy.Int Orthop. 2018; 43: 467-473
- The biology of Ewing sarcoma.ISRN Oncol. 2013; 2013: 1-7
- Prognostic factors for survival in Ewing sarcoma: a systematic review.Surg Oncol. 2018; 27: 603-610
- Diagnosis and treatment of Ewing sarcoma of the bone: a review article.J Orthop Sci. 2015; 20: 250-263
Article info
Publication history
Published online: September 18, 2021
Footnotes
Financial Disclosure: None reported.
Conflict of Interest: Lawrence M. Fallat DPM, FACFAS honoraria for Osteomed.
Identification
Copyright
© 2021 by the American College of Foot and Ankle Surgeons. All rights reserved.
