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Eighty-three patients scheduled for outpatient surgery were enrolled in this double-blind,
randomized trial designed to compare the safety and efficacy of single and multiple
doses of flurbiprofen 50 mg. and acetaminophen 300 mg. plus codeine phosphate 30 mg.
During the multiple dose segment, statistically significant differences were observed
during the first 24 hour postoperative period regarding relief of pain and pain intensity.
Flurbiprofen provided greater relief of pain than the acetaminophen with codeine phosphate
combination. This study supports the use of flurbiprofen as a suitable alternative
to acetaminophen plus codeine phosphate in the treatment of postoperative pain following
foot surgery.
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Footnotes
1The Upjohn Company: Pharmacia & Upjohn, Kalamazoo, MI.
Identification
Copyright
© 1997 American College of Foot and Ankle Surgeons. All rights reserved. Published by Elsevier Inc. All rights reserved.
